Empleos de biólogo/bióloga en Wien (Austria)

Stellenangebotsbeschreibung:

Become a member of the BioNTech Family!

BioNTech R&D Austria is a wholly owned subsidiary of BioNTech SE, focused on the development of novel antibacterial drugs to treat persistent bacterial infections. Our development programs are based on our proprietary LysinBuilder platform, which allows the targeted development of synthetic lysins for virtually any bacterial pathogen. We use a combination of randomized directed evolution approaches and rational in-silico engineering, coupled to high-throughput screening, to generate artificial lysins and develop them into drugs. The development pipeline focuses on chronic bacterial infections where antibiotics fail to cure or destroy the natural microbiomes. Our lead asset is BNT331, which we develop for the treatment of bacterial vaginosis. We also work on transforming the standard of care with lysins against several other infections and dysbioses.

Research Specialist* - High throughput screening

As Research Specialist* at BioNTech R&D Austria you will join our research team and help us bring next generation drugs from the bench into the clinic.

Contribute to design and execute series of experiments independently (depending on experience of the candidate) to support the developmental program, partially following established protocols, including:

Mammalian cell culture; cell line engineering; cell sorting

Preparation of libraries for protein screening in mammalian cells, read-out by cell sorting and next generation sequencing (NGS)

Discovery, engineering and directed evolution of enzymes

Optimize human cell lines and transfection systems for protein expression and secretion

Activity testing of lysins against bacterial strains (BSL-2 strains like Gardnerella, others)

Isolation of bacteria from human and environmental samples

Characterization of endolysins (e.g. MIC, lysis kinetic, biofilm assays)

Design new experiments and improving the established protocols

If necessary, develop capabilities in operating advanced equipment, including programming of a pipetting robot or FACS systems

Documentation of results according to the internal quality standards (near-GLP), to ensure the quality of the documentation meets the expectation of the authorities regarding a marketing authorization for a pharmaceutical

Establish research processes according to the latest microbiological technology developments (e.g. robotics and genomic data)

Maintain laboratory infrastructure, including purchasing of reagents and equipment, and constantly making materials like media and agar plates available, documenting and maintaining the inventory of biological materials

Completed university degree (BSc., MSc. or PhD) in biochemistry, biology, molecular biology or a related subject or vocational training as lab technician

At least 3 years of (cumulative) laboratory experience (Biotech experience is a plus and will be reflected in the compensation package)

Deep expertise in at least two of the following areas, ideally including publications:

Mammalian cell culture, cell line engineering

Preparation of libraries for NGS, analysis of NGS data

Engineering of proteins, combinatorial methods, library screening, FACS

Protein expression in mammalian cells

Microbiological assays involving proteins (biofilms, MIC assays, enzymatic assays etc.)

Interest in targeted pharmaceutical development

Interest in working in a team of highly skilled and motivated professionals and fluent in English

Become part of developing a new drug class in anti-infectives

Take responsibility for specific parts of the development program and work together with highly experienced researchers in executing the development plan

Pioneer new methods and processes to industrialize key research techniques

Be part of a highly motivated, multinational and fun team that believes synthetic lysins can be part of the solution to the global antibiotics crisis

A competitive compensation package that reflects th...